Among anti-inflammatory agents, a COX-2 inhibitor, which has been tested alone [123,124] and in combination regimens for cancer cachexia [125,126], should be able to improve several features of cancer cachexia including loss of body weight, muscle strength, and lean body mass in parallel with a decrease in circulating levels of pro-inflammatory cytokines, particularly IL-6 and CRP. This evidence concerns the gene IL6 and cancer.