The altered energy metabolism in cancer cells is also characterized by high utilization of glutamine, through glutaminolysis and reverse tricarboxylic acid (TCA) cycle, mainly for the production of NAPDH2 and alanine that are used for fatty and nucleic acid synthesis and for the restoration of the molecules of TCA cycle (which is inhibited as a consequence of the decreased activity of the PDH complex) for different anabolic purposes of the intensively dividing cancer cells [48]. Here, PDP1 is linked to cancer.