MAP1LC3A and obesity due to melanocortin 4 receptor deficiency: Furthermore, p300 acetylates nuclear LC3 (microtubule-associated protein 1A/1B-light chain 3; known as ATG8 in yeasts), which impairs its interaction with DOR (diabetes and obesity-regulated gene) required for its export to the cytoplasm, and thus prevents its cytoplasmic interaction with ATG7 to promote autophagy.