EP300 and retinal disorder: Following comparative transcriptome analysis in rodents exposed to light-induced retinopathy, Kawase et al. (2016) inhibited the histone acetyltransferase, EP300, a key upstream regulator of cytokine signaling axis, and found increased retinal cell apoptosis, decreased photoreceptor outer segments and increased proliferation of Müller cells following light damage; suggesting the EP300 may protect photoreceptor cells from light-induced retinal damage [164].