In breast cancer cells, BACH1 enhanced expression of matrix metalloproteinases (MMPs) and CXC-chemokine receptor 4 (CXCR4) mRNA as a transcriptional activator through direct interaction on the promoter regions of target genes to promote metastatic progression, without affecting primary breast tumor growth (Figure 2) [26,37]. Here, BACH1 is linked to breast neoplasm.