Although none of the functional data remained significant after multiple testing, these results together with those reporting a correlation between DAPK2 SNPs and DAPK2 mRNA expression in multiple tissues, including oesophagus/oesophageal junction and oesophagus/muscularis (p-values ranging from 7.6 × 10−6 to 2.3 × 10−4; Table S7), pointed to a role of the DAPK2 locus in modulating CRC risk likely through the regulation of host immune responses against components of the human microbiota. Here, DAPK2 is linked to colorectal carcinoma.