Considering these results, we decided to advance the NRG3 and DAPK2 SNPs for replication, due to showing the most significant associations with CRC risk, but also those that were associated with CRC risk at p < 0.002 (21 SNPs representing five independent signals after excluding LOC100128105, which was predicted to be a hypothetical protein by the Guide to the Human Genome (www.cshlp.org/ghg5_db/recinfo/87/8750.shtml, accessed on 13 December 2019)). Here, DAPK2 is linked to colorectal carcinoma.