Interestingly, we also found that subjects harbouring the DAPK2rs11631973G allele showed slightly increased levels of CD24 + CD38 + CD27 + IgM + B cells, a subset of transitional B cells frequently found in leukocytes from CRC patients that regulate T cell-mediated proinflammatory responses and correlate with advanced disease stages [42]. The gene discussed is CD40LG; the disease is colorectal carcinoma.