According to our present observation with MDA-MB-415 and ZR-75-1 cells, in endocrine-resistant breast cancers overexpressing MT2A, FtH, or Hsp70, rapalogues might enhance the autophagy-mediated relocation of these factors to the lysosomes, blunting LMP and further exacerbating drug-resistance. Here, MT2A is linked to breast cancer.