PD-L1 is also expressed by various tumor cells, such as melanoma, non-small-cell lung carcinoma (NSCLC), triple-negative breast cancer (TNBC), as well as within the tumor microenvironment, on tumor-associated macrophages (TAM), and myeloid-derived suppressor cells (MDSC) [5,6,7,8,9]. This evidence concerns the gene CD274 and melanoma.