Examining the connection between the main risk factors of STEMI (hypertension, diabetes mellitus, haemoglobin A1c (HbA1c) levels and smoking) and the initial PACAP levels, we found a significant (p = 0.034) positive correlation (r = 0.533) between hypertension and PACAP levels. This evidence concerns the gene ADCYAP1 and hypertensive disorder.