Alston et al. showed that the sympathetic innervation density is decreased in the ischemic regions of MI-LV, compared to the peri-infarct region and Sham control hearts, on the other hand, they did not detect PACAP-38 immunopositive fibers in the peri-infarct region [32]. Here, ADCYAP1 is linked to myocardial infarction.