FOXP3 and neoplasm: Compared to the PBS-treated control tissues, MitoX-treated shC-tumor tissues showed increased levels of Arg1+ and Foxp3+ staining, which corresponded to pro-tumoral M2-subtype macrophages and Treg cells, respectively (p = 0.037 for Arg1+ cells, p = 0.021 for Foxp3+ staining; Figure 4F,G), whereas DTIC-treated tumor tissues showed modest reduction in the levels of these cells (Figure 4F,G).