Glycoprotein VI (GP6) Signaling, Signaling by Rho Family GTPases, Rac Signaling, Amyotrophic Lateral Sclerosis Signaling, and Synaptogenesis Signaling were the top 5 canonical pathways found to be significantly affected within the HS line (p-value < 0.01) (Figure 1; Supplementary Material S3). Here, AKT1 is linked to amyotrophic lateral sclerosis.