CYP1B1 and neoplasm: Nevertheless, CYP1B1 was overexpressed in one third of the tumours with a mean value exceeding a 50-fold increase compared to CYP2E1. Significantly higher expression of CYP2E1 was found to be correlated with an invasive lobular tumour type and advanced disease compared to the invasive ductal ones, suggesting its potential role as a prognosis marker [20].