Previous studies have shown that the main antibacterial genes of C. elegans function via stimulating the innate immune defense of C. elegans against pathogenic bacteria and fungi infection, which include the C-type lectin-like domain family (clec-85, clec-60, clec-71), Saposin-like protein family (spp-12), fungus-induced protein family (fipr-22), Claudin-like in Caenorhabditis family (clc-1), and lysozyme (ilys-3 and lys-7) [45,46]. The gene discussed is CLCN1; the disease is fungal infectious disease.