CNR1 and obesity due to melanocortin 4 receptor deficiency: Functionally, while CB1 in skeletal muscle has been associated with a reduction in glucose uptake and fatty acid oxidation [33], Zheng et al. found that CB2 receptor stimulation in C2C12 myotubes by trans-β-caryophyllene promotes lipid oxidation through the sirtuin 1/peroxisome proliferator co-activator receptor 1α (SRT1/PGC1α) pathway [31], paving the way for a role of this receptor in lipid metabolism, and more generally in the management of obesity and insulin resistance.