We and others reported that the EGFR pathway is phosphorylated in IPF areas and that the activation does not rely on the occurrence of genetic lesions, which are rarely detected, but rather on an EGFR-dependent paracrine loop between epithelial and fibroblast cells, resulting in disproportionate collagen production and deposition [40,41]. The gene discussed is EGFR; the disease is idiopathic pulmonary fibrosis.