CDKN2A and idiopathic pulmonary fibrosis: In approximately 50% of IPF cases, microsatellite instability and loss of heterozygosity, targeting genes such as MYCL1, FHIT, SPARC, p16Ink4, and TP53 have also been reported, suggesting that, autonomously, IPF exhibits a high mutational background which can ultimately lead to cell cycle and apoptosis deregulation [10].