EGFR and non-small cell lung carcinoma: In this study, a non-radioactive brominated N-(3-{[2-({4-[4-acetylpiperazin-1-yl]-2-methoxyphenyl}amino)-5- (trifluoromethyl)pyrimidin-4-yl]amino}-5-bromophenyl)acrylamide (BrCO1686, Scheme 1, 9) and a radioactive brominated 9 ([77Br]BrCO1686, Scheme 2, [77Br]9) were synthesized and evaluated in vitro and in vivo using three different human NSCLC cell lines; H1975 (EGFR with L858R/T790M dual mutations), H3255 (EGFR with L858R mutation), and H441 (wild-type EGFR).