We interrogated, by single-cell RNA-sequencing, 186,916 lung cells, including a large number of epithelial cells (n = 70,030), from tumor and multiple matched normal tissues to comprehensively examine abundance and expression patterns of the SARS-CoV-2 receptor ACE2 and the pathogen’s priming proteases in the lungs of LUAD patients. This evidence concerns the gene ACE2 and neoplasm.