Furthermore, mRNA levels of TGF-β1, plasminogen activator inhibitor 1 (PAI-1), MCP-1, IL-6, pro-collagens were decreased, as well as myocardial fibrosis and collagen accumulation in deoxycorticosterone acetate/salt hypertensive rats receiving tranilast. Here, SERPINE1 is linked to Myocardial fibrosis.