Angiotensin-converting enzyme inhibitors (ACEIs) such as lisinopril, enalapril, and captopril, prevent the conversion of inactive AngI into active AngII, and have been used effectively in the treatment of several human diseases, including hypertension, congestive HF, coronary artery diseases, and diabetic nephropathy [147,148,149,150]. The gene discussed is AGT; the disease is hypertensive disorder.