Some studies have demonstrated that Nrf2-knockout mice develop cardiac hypertrophy, while activation of this nuclear factor by specific pharmacological activators such as epigallocatechin 3-gallate is effective to induce the expression and activation of Nrf2 in adipose tissue of obese mice, improves lipidemic control, and decreases the oxidative process, which could improve cardiovascular function [45,46]. The gene discussed is NFE2L2; the disease is cardiac hypertrophy.