In obesity-generated insulin resistance, WAT expresses increased levels of pro-inflammatory and proliferative adipokines, including leptin, dipeptidyl peptidase 4 (DPP-4), visfatin, toll-like receptor-4, resistin, MCP-1, TNF-α, IL-6, and IL-8, causing deterioration of the metabolic signaling of insulin and cardiovascular dysfunction [5]. The gene discussed is TNF; the disease is obesity due to melanocortin 4 receptor deficiency.