NR3C2 and obesity due to melanocortin 4 receptor deficiency: Since (i) adipocyte-MR overexpression induces a MetS-like phenotype; (ii) mitochondrial dysfunction is a main feature of AT dysfunction in obesity; (iii) pharmacological MR antagonism prevents AT mitochondrial dysfunction, OS and senescence in obese db/db mice, we hypothesise that adipocyte-MR activation leads to AT mitochondrial respiratory dysfunction, OS and MQC impairment, as well as premature AT ageing, contributing to obesity-associated metabolic complications.