In this study, we compared twenty-three different cytokines profile pattern, namely IL-1b, IL-2, IL-4, IL-6, IL-8, IL-10, IL-12p70, IL-17A, IL-33, CD14, CD54, CD62E, CD62L, CD62p, CD106, CD121b, CD154, CD178, GM-CSF, IFN-g, MIF, ST2 and TNF of dengue patients at different severity of the disease, with the aim to understand their profile during different phases of dengue and their possible association with the disease severity. This evidence concerns the gene IL2 and dengue disease.