Various mechanisms are postulated with respect to CB1 stimulation, with many controversies concerning the pathways/mechanisms/cell types/tumour progression, etc. Hence, we did an exhaustive pathway-based target mapping for all of the endocannabinoids/cannabidiols and their mimics highlighting the plausible mechanisms involved in cell death and reviewed almost all of the publications and a pictorial representation is made in Figure 5. This evidence concerns the gene CNR1 and neoplasm.