Additionally, at least in GSC and glioma cell lines, we detected lower ATIP1 expression in those cells harboring an unmethylated MGMT promoter, which means that in those cells, due to enhanced repair of O6-methylguanines by MGMT, are not very vulnerable towards TMZ treatment, reflecting a more malignant type of glioma cells. The gene discussed is MGMT; the disease is glioma.