Whilst there seemed to be no correlation of ATIP1 expression and the IDH status of either LGG and HGG (Figure S1b), there is a strict correlation of ATIP1 expression with glioma malignancy since ATIP1 is significantly downregulated in glioma cell lines compared with non-neoplastic cells of brain origin (Figure 1j), in HGG compared with LGG (Figure 1f), in pilocytic astrocytomas compared to diffuse glioma (Figure 1d) as well as in recurrent gliomas compared with first time diagnosed gliomas (Figure 1e). Here, MTUS1 is linked to central nervous system cancer.