EGFR and central nervous system cancer: Characteristics of glioma are the activation of the phosphatidylinositol 3-kinase (PI3K)/AKT, mitogen-activated protein kinase (MAPK) and epidermal growth factor receptor (EGFR) signaling pathways which regulate proliferation, survival and cancer cell motility, and which are interconnected to several other cancer-associated processes such as autophagy, ROS production, DNA damage and repair, chromosomal instability and metastasis [9,10,11,12].