To investigate the activity of the new compounds on cancer cells proliferation, compounds ZVS-08, 1 and 8 were tested on MCF-7, a breast cancer cell line showing high KV10.1 expression and low hERG expression, and on Panc1, a pancreatic cancer cell line with undetectable KV10.1 expression and high level of hERG expression. The gene discussed is KCNH2; the disease is breast cancer.