COMT and Parkinson disease: To validate our hypothesis with potentially significant implications in pathogenesis and manifestation of PD, we explored 1) the impact of inactive COMT and ALDH2 SNPs rs4680(A) and SNP rs671 (A) on the symptoms of PD patients; 2) the impact of interactions between COMT rs4680(A) and ALDH2 rs671 (A) in the motor and non-motor symptoms of PD patients.