One study found the genotype combination of ALDH2 rs671 (GG) and ADH1B rs1229984(GG) to be associated with the risk of depressive and anxiety disorders [31], and another study found a potential protective role of ALDH rs671(A) against anxiety-depressive alcohol dependence, especially in participants carrying MAOA-uVNTR 4-repeat alleles [32]. This evidence concerns the gene ALDH2 and anxiety disorder.