FOXO1 and polycystic ovary syndrome: While these reports may suggest a role of abnormal FoxO1 signaling in the development of restricted progesterone-dependent uterine receptivity and decidualization in PCOS, further molecular studies into the mechanistic association between the endometrial PGR and other transcriptional mediators of endometrial receptivity, particularly the Indian hedgehog (IHH) signaling pathway, are warranted.