ITGB3 and polycystic ovary syndrome: A study by Zhai et al. (2019) [92] suggested that metformin may improve endometrial receptivity through increasing the expression of the homeobox A10 (HOXA10) and integrin beta-3 (ITGB3) via the downregulation of miR-1910-3p and miR-491-3p in the endometrium of women with PCOS [92].