Mechanistically, Kerjaschki et al. propose that tumor cells expressing arachidonate 15-lipoxygenase-1 (ALOX15)—which catalyzes arachidonic acid to 12[S]-hydroxy-eicosatetraenoic acid (12[S]-HETE) and 15(S)-hydroxyeicosatetraenoic acid (15[S]-HETE)—can induce circular defects on lymphatic endothelium, allowing tumor cells to enter the vessel [64]. Here, ALOX15 is linked to neoplasm.