Besides, the recent report showed that gene electrotransfer of plasmid encoding shRNA against tumor component, herein, melanoma cell adhesion molecule (pMCAM) elicited anti-tumor dual-action including a vascular-targeted effect mediated by silencing of MCAM and an immunological effect mediated by the presence of plasmid DNA in the cytosol activating DNA sensors [21]. This evidence concerns the gene MCAM and neoplasm.