Of the four DETmRs, IKZF4 (zinc finger protein Eos) plays an essential role in CD4+ regulatory T cells (Tregs) programming and affects multiple aspects of Treg suppressor function [34,35], AGRN (agrin) is involved in cervical tumourigenesis and sepsis-induced neuromuscular dysfunction [36,37], IFI44 (interferon-induced protein 44) can restrict viral activity and replication [38,39], and XM_020112654.1 is a uncharacterized protein with unknown function. The gene discussed is CD4; the disease is Sepsis.