TP53 and neoplasm: Within our data the pattern of p53 was different in ER positive and ER negative groups, with decreasing numbers of positive p53 cases in the ER negative subgroup and increasing numbers in the ER positive subgroup, where there is again a possibility that the ER positive tumours might have pathological relation to somatic p53 mutations in older women as a result of long standing oestrogen stimulation for cell division.