We detected that the G/G genotype and G allele of the c.-227G > C—NOS2 SNP were associated with a decreased occurrence of a stroke (bootstrap crude ORs 0.69; 0.51–0.94 95% CI; SP 0.710 and 0.77; 0.63–0.93; SP 560, respectively). The gene discussed is NOS2; the disease is Stroke.