In conclusion, our results showed that the genetics variants in the SOD2 (c.47T > C; rs4880), GPX4 (c.660T > A; rs713041), NOS1 (g.117803515C > T; rs1879417) and NOS2 (c.1823C > T; rs2297518 and c.-227G > C; rs10459953) genes may be associated with individual susceptibility to a stroke. The gene discussed is GPX4; the disease is stroke disorder.