PITX2 and Stroke: To date, a stroke can be genetically associated with multiple susceptibility loci, including 9p21 (CDKN2A/CDKN2B/ANRIL), 7p21 (HDAC9), 6p21.1, 4p25 (PITX2), 16q22 (ZFHX3), 9q34 (ABO) [17].