Gene expression profiling has also enabled the distinguishing of upregulated genes, with an important role in the pathogenesis of ENKTCL including BIRC5 encoding for survivin, MYC, PD-L1, RUNX3, AURKA, and PDGFRA. MYC is a well-known oncogene related to aggressive clinical behavior in mature B cell lymphomas [164], and is associated with NOTCH1 mutations in T cell lymphomas [165]. This evidence concerns the gene MYC and T-cell non-Hodgkin lymphoma.