Moreover, the expression of IL-1α, TNFα, TGFα, EGF, amphiregulin, HB-EGF, FGF2, FGF3, and VEGFA is higher in Ikkα+/− skin than in Ikkα+/+ skin, treated with a chemical skin-tumor-promoter (inflammatory irritant). This evidence concerns the gene CHUK and skin neoplasm.