SNPs in genes that promote fat accumulation in hepatocytes as well as reportedly promoting NAFLD-HCC include rs738409 in patatin-like phospholipase domain-containing 3 (PNPLA3) [13,14] and rs58542926 in transmembrane-6 superfamily member-2 (TM6SF2) [7,15,16,17]. The gene discussed is PNPLA3; the disease is metabolic dysfunction-associated steatotic liver disease.