In patients with anxiety/depression Bifidobacterium, Alistipes, Prevotella, Parabacteroides, Lachnospiraceae, Anaerostipes, Oscillibacter, Faecalibacterium, Ruminococcus, Clostridium, Megamonas, Streptococcus, Klebsiella, and Phascolarctobacterium are changing towards decreasing dopamine (DOPAC), homovanillic acid, hippocampus 5-HT, BDNF expression, and circulatory IL-10 while increasing plasma stress hormone [63,64]. This evidence concerns the gene IL10 and major depressive disorder.