These observations are further supported by the results from the present study, showing that, upon knockdown of the Lcn-2 receptor, tumor spheroids showed not only reduced tumor growth, but also reduced metastasis-related mesenchymal-state associated genes such as ZEB1 or CDH2, whereas the epithelial markers CDH1 or KRT-19 were significantly enhanced. This evidence concerns the gene CDH2 and neoplasm.