LCN2 and neoplasm: Taking into account that MΦ-derived Lcn-2 was significantly correlated to tumor onset and metastasis and the enhanced amount of intracellularly trapped iron within Lcn-2−/− TAM, we further hypothesize that tumor cells from Lcn-2−/− mice show reduced growth and metastatic potential due to lower iron availability in the TME (Figure 4a).