Thus, the infection of cultured pancreatic adenocarcinoma cells with the vMyx-mLIGHT-FLuc/tdTr construct leads to a marked-to-significant reduction in cell viability, suggesting that oncolytic treatment of even the semi- and non-permissive types of cancers may provide sizeable therapeutic benefits in vivo, as well as still delivering therapeutic proteins such as LIGHT, if expressed under early virus promoter control. Here, TNFSF14 is linked to pancreatic adenocarcinoma.