The results of MLB on BLM-treated mice also showed the same trends: the level of Smad3 phosphorylation and release of TGF-β in serum could be decreased by MLB treatment; we also observed that MLB decreased Smad2 phosphorylation and recovered the downregulation of Smad7, but MLB still could not affect the level of JNK and Akt phosphorylation (Figure 6a,b). The gene discussed is SMAD2; the disease is Bloom syndrome.