For example, HNF1A-AS1 binds to the C-terminal of Src homology region 2 (SH2) domain-containing phosphatase 1 (SHP-1) protein and increases the phosphatase activity of SHP-1, which subsequently promotes anti-tumor effects of HNF-1α and HNF1A-AS1 [104]. This evidence concerns the gene HNF1A and neoplasm.