Therefore, to analyze the mechanism of worst response to ICB in NSCLC patients with NDB, we systematically explored multiple indicators related to immunophenotypes in patients with NSCLC harboring mutations in KEAP1 and FAT1, including TMB, PD-L1 expression, neoantigen, immune cell infiltration, and immune-regulatory mRNA expression. The gene discussed is CD274; the disease is non-small cell lung carcinoma.