In 5XFAD mouse models (expressing human APP and PSEN1 transgenes associating five AD-linked mutations: the Swedish (K670N/M671L), Florida (I716V), and London (V717I) mutations in APP, and the M146L and L286V mutations in PSEN1, the genetic blockade of PKR reduced cognitive memory impairment, neurodegeneration, neuroinflammation, and brain Aβ 1-42 accumulation [33]. This evidence concerns the gene EIF2AK2 and Alzheimer disease.