The goal of the present review is to analyze the involvement of a specific signaling pathway in AD, starting with the cellular triggering of the eukaryotic initiation factor 2 α (eIF2α) kinase II (PKR) in brain cells and leading to the final activation of the receptor-interacting serine/threonine-protein kinase 1 (RIPK1). Here, RIPK1 is linked to Alzheimer disease.