In the context of HNSCC, Ramos-Vega et al. were able to demonstrate a significant association between α-SMA-positive CAF cells and laryngeal carcinomas, advanced clinical stages of HNSCC cancers, and lower tumor differentiation; there was, however, no observable association with PDPN staining and clinicopathological variables or presence of CAFs [7]. Here, ACTA1 is linked to head and neck squamous cell carcinoma.