Likewise studying POSTN’s effects on RCC, Chuanyu et al. found that CAF-derived POSTN is a critical driver in RCC cell growth and migration through interaction with integrins αvβ3 and αvβ5, which activate the focal adhesion kinase/c-Jun N-terminal kinase pathway and enhance CCRCC cell attachment to increase metastatic capabilities. This evidence concerns the gene JUN and renal cell carcinoma.