Their study showed that CAF cells were able to induce resistance to doxorubicin through high mobility group box 1 (HMGB1) production, as pre-treatment of breast cancer cells with CAF-conditioned media induced a degree of resistance to doxorubicin that corresponded to levels of secreted HMGB1, compared to negligible resistance in non-tumor-associated fibroblast-conditioned media. This evidence concerns the gene HMGB1 and neoplasm.