Hormone-secreting PitNETs overproduce growth hormone (GH), adrenocorticotropic hormone (ACTH), prolactin (PRL), or rarely, hormones including follicle-stimulating (FSH), luteinizing (LH) or thyroid-stimulating hormone (TSH), leading to different systemic endocrine disorders, such as acromegaly, Cushing’s disease, and others. Here, POMC is linked to endocrine system disorder.