TET2 and chronic myelomonocytic leukemia: As a matter of fact, in another study focusing only on biallelic TET2-mutant MN, we confirmed that biallelic inactivation is frequently observed in MN and that this configuration is a typical feature of older patients with monocytosis (also outside the context of an overt CMML diagnosis), CMML, normal karyotype, and lower-risk disease.