Similarly in melanoma and lung cancer, colonizing tumor cells produce VEGF-A, LOX, TNF-α, and inflammatory serum amyloid A3 in a HIF-1-dependent manner which leads to the recruitment of bone marrow-derived cells, metastatic niche formation, and remodeling of the extracellular matrix to facilitate invasion [136]. The gene discussed is HIF1A; the disease is neoplasm.