EGLN2 and breast carcinoma: Previously, our research indicated that PHD1 (EglN2) promotes the binding of peroxisome proliferator-activated receptor-γ coactivator (PGC1α) with NRF1 under hypoxia and subsequently maintains microchondrial biogenesis in breast cancer through inducing transcription of ferridoxin reductase (FDXR) [183].