HDAC6 enables α-tubulin deacetylation in hypoxic conditions, allowing EMT factor, SMAD3, to translocate to the nucleus; HDAC6 inhibitors have been shown to inhibit metastasis in TNBC and angiogenesis in gastric cancer cells by reducing HIF-1α and VEGF levels [196,197]. Here, HDAC6 is linked to gastric cancer.