The intensity of the staining score of estrogen receptors in hepatoid cells reached 0.83 ± 0.70 in the adenoma group, 0.92 ± 0.80 in the epithelioma group and 0.20 ± 0.45 in the carcinoma group and the differences between the groups were not significant (p > 0.05). The gene discussed is ESR1; the disease is adenoma.