A proportional score of hepatoid cells showing the expression of estrogen receptors reached 0.83 ± 0.70 in the adenoma group, 0.92 ± 0.79 in the epithelioma group and 0.20 ± 0.45 in the carcinoma group and the differences between the groups were not significant (p > 0.05). This evidence concerns the gene ESR1 and epithelial neoplasm.