Compared with other PD-1 inhibitors (pembrolizumab and atezolizumab), nivolumab has been estimated as the best option in terms of anti-tumor efficacy, while atezolizumab is better at reducing adverse events, and pembrolizumab monotherapy was shown to be the best especially for patients with PD-L1 ≥ 50% [57]. The gene discussed is PDCD1; the disease is neoplasm.