In cancer, miR-21 and miR-29a from tumor-derived EVs/Exs bind to Toll-like receptors, such as human TLR8, and lead to TLR-mediated NFκB activation and secretion of pro-metastatic inflammatory cytokines, which in turn promotes tumor growth and metastasis [32]. The gene discussed is NFKB1; the disease is neoplasm.