However, it has been recently described that IL-1β and IL-18 play an important role in the initiation and progression of the idiopathic inflammatory myopathies, a heterogeneous group of chronic disorders that are characterized by the predominant inflammation in muscle tissue and includes dermatomyositis, polymyositis, and inclusion body myositis [21,35,36]. The gene discussed is IL18; the disease is dermatomyositis.