Type I (IFNα, and IFNβ), type II (IFNγ) and type III (IFNλ) IFNs are cytokines produced during infections, some other cellular stress conditions, and upon aberrant recognition of ‘self’ molecules in auto-immune disorders collectively known as interferonopathies [31,245,246,247]. The gene discussed is IFNA1; the disease is infection.