Mandourah (2018) [16] found miR-122-5p and miR-4516 to be correlated with fragility fracture and use of the target prediction programmes, miWalk, miRanda, RNA22 and Targetscan, with the search term osteoporosis, which suggested that eight mRNAs, including BMP2K, FSHB, IGF1R, PTHLH, Runx2, SPARC, TSC22D3 and the vitamin D receptor, would be potential targets of both miR-122-5p and miR-4516. Here, SPARC is linked to osteoporosis.