Ser293 is also highly modified (desphosphorylated) in hepatocellular carcinomas (HCCs) induced by Myc over-expression and in hepatoblastomas induced by the co-expression of mutant forms of β-catenin and yes-associated protein, which also dysregulate Myc [71,74,76,81,82] The resultant activation of PDH (and hence PDC) resulting from this modification was proposed to represent a means by which limiting amounts of pyruvate could be efficiently utilized by the TCA cycle to sustain both glycolysis and Oxphos in these rapidly growing tumors. Here, PDC is linked to hepatocellular carcinoma.