MYC and hepatocellular carcinoma: Ser293 is also highly modified (desphosphorylated) in hepatocellular carcinomas (HCCs) induced by Myc over-expression and in hepatoblastomas induced by the co-expression of mutant forms of β-catenin and yes-associated protein, which also dysregulate Myc [71,74,76,81,82] The resultant activation of PDH (and hence PDC) resulting from this modification was proposed to represent a means by which limiting amounts of pyruvate could be efficiently utilized by the TCA cycle to sustain both glycolysis and Oxphos in these rapidly growing tumors.